Orthogonal Gelations to Synthesize Core–Shell Hydrogels Loaded with Nanoemulsion‐Templated Drug Nanoparticles for Versatile Oral Drug Delivery (Adv. Healthcare Mater. 31/2023)
Name
Adv Healthcare Materials - 2023 - Attia - Orthogonal Gelations to Synthesize Core Shell Hydrogels Loaded with.pdf
Description
Published version
Size
4.32 MB
Format
Adobe PDF
Checksum (MD5)
81a558109f89531ec86d9e853953cb17
Author(s)
Attia, Lucas
Chen, Liang‐Hsun
Doyle, Patrick S
Date Issued
December 2023
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Attia, Lucas, Chen, Liang‐Hsun and Doyle, Patrick S. 2023. "Orthogonal Gelations to Synthesize Core–Shell Hydrogels Loaded with Nanoemulsion‐Templated Drug Nanoparticles for Versatile Oral Drug Delivery (Adv. Healthcare Mater. 31/2023)." Advanced Healthcare Materials, 12 (31).
Version
Final published version
Abstract
Hydrophobic active pharmaceutical ingredients (APIs) are ubiquitous in the drug development pipeline, but their poor bioavailability often prevents their translation into drug products. Industrial processes to formulate hydrophobic APIs are expensive, difficult to optimize, and not flexible enough to incorporate customizable drug release profiles into drug products. Here, a novel, dual-responsive gelation process that exploits orthogonal thermo-responsive and ion-responsive gelations is introduced. This one-step “dual gelation” synthesizes core–shell (methylcellulose-alginate) hydrogel particles and encapsulates drug-laden nanoemulsions in the hydrogel matrices. In situ crystallization templates drug nanocrystals inside the polymeric core, while a kinetically stable amorphous solid dispersion is templated in the shell. Drug release is explored as a function of particle geometry, and programmable release is demonstrated for various therapeutic applications including delayed pulsatile release and sequential release of a model fixed-dose combination drug product of ibuprofen and fenofibrate. Independent control over drug loading between the shell and the core is demonstrated. This formulation approach is shown to be a flexible process to develop drug products with biocompatible materials, facile synthesis, and precise drug release performance. This work suggests and applies a novel method to leverage orthogonal gel chemistries to generate functional core–shell hydrogel particles.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adhm.202370200
