Antibiotic efficacy — context matters
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1-s2.0-S1369527417300863-main.pdf
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797.67 KB
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Adobe PDF
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8598585878feaad6f2575012ef99a814
Author(s)
Yang, Jason Hung-Ying
Bening, Sarah
Collins, James J.
Date Issued
October 2017
Journal
Current Opinion in Microbiology
Publisher
Elsevier BV
Citation
Yang, Jason H et al. “Antibiotic Efficacy — Context Matters.” Current Opinion in Microbiology 39 (October 2017): 73–80 © 2017 The Authors
Version
Final published version
Abstract
Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each contribute to antibiotic-induced cell death. Moreover, environmental factors such as oxygen availability, extracellular metabolites, population heterogeneity and multidrug contexts alter antibiotic efficacy by impacting bacterial metabolism and stress responses. Here we review recent studies on antibiotic efficacy and highlight insights gained on the involvement of cellular respiration, redox stress and altered metabolism in antibiotic lethality. We discuss the complexity found in natural environments and highlight knowledge gaps in antibiotic lethality that may be addressed using systems approaches.
MIT Department
Institute for Medical Engineering and Science
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.MIB.2017.09.002
