Single-cell transcriptomics of the mouse thalamic reticular nucleus
Name
1017490528-MIT.pdf
Size
8.06 MB
Format
Adobe PDF
Checksum (MD5)
12a72b51edbc6ecd0c6d12b52967630a
Author(s)
Li, Taibo,M. Eng.Massachusetts Institute of Technology.
Advisor(s)
Guoping Feng and Kasper Lage.
Alternative Title
Single-cell transcriptomics of the mouse TRN
Date Issued
2017
Publisher
Massachusetts Institute of Technology
Abstract
The thalamic reticular nucleus (TRN) is strategically located at the interface between the cortex and the thalamus, and plays a key role in regulating thalamo-cortical interactions. Current understanding of TRN neurobiology has been limited due to the lack of a comprehensive survey of TRN heterogeneity. In this thesis, I developed an integrative computational framework to analyze the single-nucleus RNA sequencing data of mouse TRN in a data-driven manner. By combining transcriptomic, genetic, and functional proteomic data, I discovered novel insights into the molecular mechanisms through which TRN regulates sensory gating, and suggested targeted follow-up experiments to validate these findings.
Description
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 44-49).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
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