Optogenetically Induced Behavioral and Functional Network Changes in Primates
Name
Gerits-2012-Optogenetically Indu.pdf
Size
773.85 KB
Format
Adobe PDF
Checksum (MD5)
14800465e0bd7ef939ad9941abbf2128
Author(s)
Gerits, Annelies
Farivar, Reza
Rosen, Bruce R.
Wald, Lawrence L.
Vanduffel, Wim
Boyden, Edward
Date Issued
July 2012
Journal
Current Biology
Publisher
Elsevier
Citation
Gerits, Annelies, Reza Farivar, Bruce R. Rosen, Lawrence L. Wald, Edward S. Boyden, and Wim Vanduffel. “Optogenetically Induced Behavioral and Functional Network Changes in Primates.” Current Biology 22, no. 18 (September 2012): 1722–1726. © 2012 Elsevier Ltd.
Version
Final published version
Abstract
Optogenetics is currently the state-of-the-art method for causal-oriented brain research. Despite an increasingly large number of invertebrate and rodent studies showing profound electrophysiological and behavioral effects induced by optogenetics, only two primate studies have reported modulation of local single-cell activity but with no behavioral effects. Here, we show that optogenetic stimulation of cortical neurons within rhesus monkey arcuate sulcus, during the execution of a visually guided saccade task, evoked significant and reproducible changes in saccade latencies as a function of target position. Moreover, using concurrent optogenetic stimulation and opto-fMRI), we observed optogenetically induced changes in fMRI activity in specific functional cortical networks throughout the monkey brain. This is critical information for the advancement of optogenetic primate research models and for initiating the development of optogenetically based cell-specific therapies with which to treat neurological diseases in humans.
MIT Department
Massachusetts Institute of Technology. Synthetic Neurobiology Group
Massachusetts Institute of Technology. Media Laboratory
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cub.2012.07.023
