Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling
Name
jcb_201908224.pdf
Description
Published version
Size
1.52 MB
Format
Adobe PDF
Checksum (MD5)
4b8317c9d474cfef80647e6f6f434bf8
Author(s)
Nguyen, Kim Bich
Spranger, Stefani
Date Issued
2020
Journal
The Journal of Cell Biology
Publisher
Rockefeller University Press
Version
Final published version
Abstract
The development of cancer immunotherapies has been guided by advances in our understanding of the dynamics between tumor cells and immune populations. An emerging consensus is that immune control of tumors is mediated by cytotoxic CD8+ T cells, which directly recognize and kill tumor cells. The critical role of T cells in tumor control has been underscored by preclinical and clinical studies that observed that T cell presence is positively correlated with patient response to checkpoint blockade therapy. However, the vast majority of patients do not respond or develop resistance, frequently associated with exclusion of T cells from the tumor microenvironment. This review focuses on tumor cell–intrinsic alterations that blunt productive anti-tumor immune responses by directly or indirectly excluding effector CD8+ T cells from the tumor microenvironment. A comprehensive understanding of the interplay between tumors and the immune response holds the promise for increasing the response to current immunotherapies via the development of rational novel combination treatments.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1083/JCB.201908224
