Cross-sectional assessment of SARS-CoV-2 viral load by symptom status in Massachusetts congregate living facilities
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jiab367.pdf
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Accepted version
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654.42 KB
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Author(s)
Lennon, Niall J
Bhattacharyya, Roby P
Mina, Michael J
Rehm, Heidi L
Hung, Deborah T
Smole, Sandra
Woolley, Ann
Lander, Eric S
Gabriel, Stacey B
Date Issued
2021
Journal
Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Citation
Lennon, Niall J, Bhattacharyya, Roby P, Mina, Michael J, Rehm, Heidi L, Hung, Deborah T et al. 2021. "Cross-sectional assessment of SARS-CoV-2 viral load by symptom status in Massachusetts congregate living facilities." Journal of Infectious Diseases, 224 (10).
Version
Author's final manuscript
Abstract
Abstract
Transmission of coronavirus disease 2019 (COVID-19) from people without symptoms confounds societal mitigation strategies. From April to June 2020, we tested nasopharyngeal swabs by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) from 15 514 staff and 16 966 residents of nursing homes and assisted living facilities in Massachusetts. Cycle threshold (Ct) distributions were very similar between populations with (n = 739) and without (n = 2179) symptoms at the time of sampling (mean Ct, 25.7 vs 26.4; ranges 12–38). However, as local cases waned, those without symptoms shifted towards higher Ct. With such similar viral load distributions, existing testing modalities should perform comparably regardless of symptoms, contingent upon time since infection.
Transmission of coronavirus disease 2019 (COVID-19) from people without symptoms confounds societal mitigation strategies. From April to June 2020, we tested nasopharyngeal swabs by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) from 15 514 staff and 16 966 residents of nursing homes and assisted living facilities in Massachusetts. Cycle threshold (Ct) distributions were very similar between populations with (n = 739) and without (n = 2179) symptoms at the time of sampling (mean Ct, 25.7 vs 26.4; ranges 12–38). However, as local cases waned, those without symptoms shifted towards higher Ct. With such similar viral load distributions, existing testing modalities should perform comparably regardless of symptoms, contingent upon time since infection.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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DOI of Published Version
https://doi.org/10.1093/INFDIS/JIAB367
