Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval
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nihms-774309.pdf
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Author(s)
Beyeler, Anna
Namburi, Praneeth
Glober, Gordon
Simonnet, Clemence
Calhoon, Gwendolyn G
Conyers, Garrett F.
Luck, Robert
Wildes, Craig P
Tye, Kay M
Date Issued
March 2016
Journal
Neuron
Publisher
Elsevier/Cell Press
Citation
Beyeler, Anna et al. “Divergent Routing of Positive and Negative Information from the Amygdala During Memory Retrieval.” Neuron 90, 2 (April 2016): 348–361 © 2016 Elsevier Inc
Version
Author's final manuscript
Abstract
Although the basolateral amygdala (BLA) is known to play a critical role in the formation of memories of both positive and negative valence, the coding and routing of valence-related information is poorly understood. Here, we recorded BLA neurons during the retrieval of associative memories and used optogenetic-mediated phototagging to identify populations of neurons that synapse in the nucleus accumbens (NAc), the central amygdala (CeA), or ventral hippocampus (vHPC). We found that despite heterogeneous neural responses within each population, the proportions of BLA-NAc neurons excited by reward predictive cues and of BLA-CeA neurons excited by aversion predictive cues were higher than within the entire BLA. Although the BLA-vHPC projection is known to drive behaviors of innate negative valence, these neurons did not preferentially code for learned negative valence. Together, these findings suggest that valence encoding in the BLA is at least partially mediated via divergent activity of anatomically defined neural populations.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.NEURON.2016.03.004
