Pharmaceutical Properties of Nanoparticulate Formulation Composed of TPGS and PLGA for Controlled Delivery of Anticancer Drug
Name
IMST017.PDF
Size
520.27 KB
Format
Adobe PDF
Checksum (MD5)
590e03c095e256ce7cdd2f7b6461e219
Author(s)
Mu, L.
Chan-Park, Mary Bee-Eng
Yue, Chee Yoon
Feng, S.S.
Date Issued
January 2004
Series/Report no.
Innovation in Manufacturing Systems and Technology (IMST);
Abstract
A suitable management of the pharmaceutical property is needed and helpful to design a desired nanoparticulate delivery system, which includes the carrier nature, particle size and size distribution, morphology, surfactant stabiliser according to the technique applied, drug-loading ratio and encapsulation efficiency, surface property, etc. All will influence the in vitro release, in vivo behaviour and tissue distribution of administered particulate drug loaded nanoparticles. The main purpose of the present work was to determine the effect of drug loading ratio when employing TPGS as surfactant stabiliser and/or matrix material to improve the nanoparticulate formulation. The model drug employed was paclitaxel.
Subjects
biomaterials
drug delivery
surfactant stabiliser
Paclitaxel
D-α -tocopheryl polyethylene glycol 1000 succinate.
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