Toward a consensus in protein structure nomenclature
Name
Toward a consensus in protein structure nomenclature.pdf
Description
Published version
Size
361.05 KB
Format
Adobe PDF
Checksum (MD5)
f6b6dcca4ca771271f1e004dc39b8a92
Author(s)
DaSilva, Linder C
Gurry, Thomas Jerome
Stultz, Collin M
Date Issued
December 2014
Journal
Intrinsically Disordered Proteins
Publisher
Informa UK Limited
Citation
DaSilva, Linder C et al. "Toward a consensus in protein structure nomenclature." Intrinsically Disordered Proteins 2, 1 (December 2012): e970902 © The Authors
Version
Final published version
Abstract
In a recent article, published in Intrinsically Disordered Proteins, a valuable consensus view regarding the nomenclature for disordered proteins was presented.1 In this work the authors present a thoughtful and systemic review of terms that have been used in the literature to describe proteins that sample a heterogeneous set of structures during their biological lifetime. We agree that the term "intrinsically disordered proteins" (IDPs) is an appropriate single descriptor to refer to this particular class of proteins, although it does not fully capture much of the nuanced complexities that are inherent to this class. In what follows we suggest a refinement to this nomenclature based on an analysis of the underlying ensemble that describes the thermally accessible states of a given IDP.
MIT Department
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Computational and Systems Biology Program
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution Noncommercial 3.0 unported license
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DOI of Published Version
https://doi.org/10.4161/idp.29700
