Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China
Name
Chen_Sequential reassortments.pdf
Size
1.57 MB
Format
Adobe PDF
Checksum (MD5)
4a43dc9f506cc4d905077bef5adabc31
Author(s)
Wu, Aiping
Su, Chunhu
Wang, Dayan
Peng, Yousong
Liu, Mi
Hua, Sha
Li, Tianxian
Gao, George F.
Tang, Hong
Chen, Jianzhu
Date Issued
October 2013
Journal
Cell Host & Microbe
Publisher
Elsevier B.V.
Citation
Wu, Aiping, Chunhu Su, Dayan Wang, Yousong Peng, Mi Liu, Sha Hua, Tianxian Li, et al. “Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China.” Cell Host & Microbe 14, no. 4 (October 2013): 446–452. © 2013 Elsevier Inc.
Version
Final published version
Abstract
Initial genetic characterizations have suggested that the influenza A (H7N9) viruses responsible for the current outbreak in China are novel reassortants. However, little is known about the pathways of their evolution and, in particular, the generation of diverse viral genotypes. Here we report an in-depth evolutionary analysis of whole-genome sequence data of 45 H7N9 and 42 H9N2 viruses isolated from humans, poultry, and wild birds during recent influenza surveillance efforts in China. Our analysis shows that the H7N9 viruses were generated by at least two steps of sequential reassortments involving distinct H9N2 donor viruses in different hosts. The first reassortment likely occurred in wild birds and the second in domestic birds in east China in early 2012. Our study identifies the pathways for the generation of diverse H7N9 genotypes in China and highlights the importance of monitoring multiple sources for effective surveillance of potential influenza outbreaks.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.chom.2013.09.001
