Biomaterials for non-viral delivery of nucleic acid drugs
Name
1193027179-MIT.pdf
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910.35 KB
Format
Adobe PDF
Checksum (MD5)
14d946cb124c17db958d3a9541be3fc0
Author(s)
Bader, Andrew R.
Advisor(s)
Daniel Anderson.
Date Issued
2020
Publisher
Massachusetts Institute of Technology
Abstract
Significant progress has been made in the field of biomaterials for non-viral delivery of macromolecules. A wide variety of distinct types of novel biomaterials, in combination with corresponding cutting-edge therapeutic systems and technologies, have been developed and have shown highly promising therapeutic efficacies in research studies published. Furthermore, a number of these technologies are rapidly progressing to and through clinical trial. Specifically, substantial progress related to the development of drug delivery technologies including lipid nanoparticulate formulations, polymer nanoparticulate formulations, and other types of nanoparticulate formulations may lead to the development of substantial libraries of novel, highly effective, next-generation therapeutic technologies. The motivation of this thesis is to review these state-of-the-art technologies.
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020
Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 63-97).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
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