WNT Signaling in Cancer Immunosurveillance
Name
WNTsignalingincancerimmunosurveillance-ONLINEFIRST.pdf
Description
Accepted version
Size
2.84 MB
Format
Adobe PDF
Checksum (MD5)
527e91d3750c262e74a074dfe184f199
Author(s)
Spranger, Stefani
Date Issued
January 2019
Journal
Trends in Cell Biology
Publisher
Elsevier BV
Citation
Galluzzi, Lorenzo et al. “WNT Signaling in Cancer Immunosurveillance.” Trends in Cell Biology 29 (2019): 44-65 © 2019 The Author(s)
Version
Author's final manuscript
Abstract
Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoevasion and resistance to multiple immunotherapeutics, including immune checkpoint blockers. Here, we discuss the molecular and cellular mechanisms through which WNT signaling influences cancer immunosurveillance and present potential therapeutic avenues to harness currently available WNT modulators for cancer immunotherapy.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.tcb.2018.08.005
