Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes
Name
Shabalina-2010-Distinct Patterns of Expression and Evolution.pdf
Size
210.1 KB
Format
Adobe PDF
Checksum (MD5)
3c5ed6a3944f6da3ed7e9bcf4bc4b83f
Author(s)
Shabalina, Svetlana A.
Ogurtsov, Aleksey Y.
Spiridonov, Alexey Nikolaevich
Novichkov, Pavel S.
Spiridonov, Nikolay A.
Koonin, Eugene V.
Date Issued
April 2010
Journal
Molecular Biology and Evolution
Publisher
Oxford University Press on behalf of the Society for Molecular Biology and Evolution
Citation
Shabalina, S. A. et al. “Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes.” Molecular Biology and Evolution 27.8 (2010): 1745–1749. Web.
Version
Final published version
Abstract
Comparison of expression levels and breadth and evolutionary rates of intronless and intron-containing mammalian genes shows that intronless genes are expressed at lower levels, tend to be tissue specific, and evolve significantly faster than spliced genes. By contrast, monomorphic spliced genes that are not subject to detectable alternative splicing and polymorphic alternatively spliced genes show similar statistically indistinguishable patterns of expression and evolution. Alternative splicing is most common in ancient genes, whereas intronless genes appear to have relatively recent origins. These results imply tight coupling between different stages of gene expression, in particular, transcription, splicing, and nucleocytosolic transport of transcripts, and suggest that formation of intronless genes is an important route of evolution of novel tissue-specific functions in animals.
MIT Department
Massachusetts Institute of Technology. Department of Mathematics
Terms of Use
Creative Commons Attribution Non-Commercial
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1093/molbev/msq086
