Surface Requirements for Optimal Biosensing with Disposable Gold Electrodes
Name
acsmeasuresciau.1c00042.pdf
Description
Published version
Size
4.88 MB
Format
Adobe PDF
Checksum (MD5)
2f54539e2f597d5e6535734b981b02f9
Author(s)
Zamani, Marjon
Yang, Victoria
Maziashvili, Lizi
Fan, Gang
Klapperich, Catherine M
Furst, Ariel L
Date Issued
2022
Journal
ACS Measurement Science Au
Publisher
American Chemical Society (ACS)
Citation
Zamani, Marjon, Yang, Victoria, Maziashvili, Lizi, Fan, Gang, Klapperich, Catherine M et al. 2022. "Surface Requirements for Optimal Biosensing with Disposable Gold Electrodes." ACS Measurement Science Au, 2 (2).
Version
Final published version
Abstract
Electrochemical biosensors are promising technologies for detection and monitoring in low-resource settings due to their potential for easy use and low-cost instrumentation. Disposable gold screen-printed electrodes (SPEs) are popular substrates for these biosensors, but necessary dopants in the ink used for their production can interfere with biosensor function and contribute to the heterogeneity of these electrodes. We recently reported an alternative disposable gold electrode made from gold leaf generated using low-cost, equipment-free fabrication. We have directly compared the surface topology, biorecognition element deposition, and functional performance of three disposable gold electrodes: our gold leaf electrodes and two commercial SPEs. Our leaf electrodes significantly outperformed the SPEs for reproducible and effective biosensing in a DNase I assay and are nearly an order of magnitude less expensive than the SPEs. Therefore, these electrodes are promising for further development as point-of-care diagnostics, especially in low-resource settings.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/ACSMEASURESCIAU.1C00042
