The FEAR network
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FearNetwork.pdf
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1.02 MB
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Author(s)
Rock, Jeremy Michael
Amon, Angelika B
Date Issued
December 2009
Journal
Current Biology
Publisher
Elsevier Ltd.
Citation
Rock, Jeremy M., and Angelika Amon. “The FEAR Network.” Current Biology 19.23 (2009): R1063–R1068. Web.
Version
Author's final manuscript
Abstract
Mitosis is governed by the oscillation of cyclin dependent kinase (CDK) activity and
ubiquitin-dependent proteolysis. Entry into mitosis is initiated by mitotic cyclin-CDK
activation. Anaphase onset occurs upon activation of the Anaphase Promoting
Complex/Cyclosome (APC/C), a ubiquitin ligase that promotes the destruction of the
anaphase inhibitor Securin. Destruction of Securin initiates chromosome segregation by
activation of the protease Separase, allowing it to cleave a subunit of the cohesin
complexes that hold the duplicated sister chromatids together. Upon completion of
nuclear division cells exit from mitosis, a process defined by the inactivation of CDKs,
disassembly of the mitotic spindle, and cytokinesis. In the budding yeast S. cerevisiae, a
signaling network known as the FEAR network is critical to ensure accurate anaphase
chromosome segregation and the integration of this process with other anaphase
events. Here, we summarize what is known about the regulation and function of the
FEAR network in budding yeast and discuss the potential for conserved FEAR network
functions in other eukaryotes.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.cub.2009.10.002
