Frontal language areas do not emerge in the absence of temporal language areas: A case study of an individual born without a left temporal lobe
Name
2021.05.28.446230v2.full.pdf
Description
Submitted version
Size
1.15 MB
Format
Adobe PDF
Checksum (MD5)
f84da1a6dea6d9525849a49e29cb24bf
Author(s)
Tuckute, Greta
Paunov, Alexander
Kean, Hope
Small, Hannah
Mineroff, Zachary
Blank, Idan
Fedorenko, Evelina
Date Issued
2022
Journal
Neuropsychologia
Publisher
Elsevier BV
Citation
Tuckute, Greta, Paunov, Alexander, Kean, Hope, Small, Hannah, Mineroff, Zachary et al. 2022. "Frontal language areas do not emerge in the absence of temporal language areas: A case study of an individual born without a left temporal lobe." Neuropsychologia, 169.
Version
Original manuscript
Abstract
Language processing relies on a left-lateralized fronto-temporal brain network. How this network emerges ontogenetically remains debated. We asked whether frontal language areas emerge in the absence of temporal language areas through a 'deep-data' investigation of an individual (EG) born without her left temporal lobe. Using fMRI methods that have been validated to elicit reliable individual-level responses, we find that-as expected for early left-hemisphere damage-EG has a fully functional language network in her right hemisphere (comparable to the LH network in n = 145 controls) and intact linguistic abilities. However, we detect no response to language in EG's left frontal lobe (replicated across two sessions, 3 years apart). Another network-the multiple demand network-is robustly present in frontal lobes bilaterally, suggesting that EG's left frontal cortex can support non-linguistic cognition. The existence of temporal language areas therefore appears to be a prerequisite for the emergence of the frontal language areas.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.NEUROPSYCHOLOGIA.2022.108184
