Intrachain Dynamics of Large dsDNA Confined to Slitlike Channels
Name
Jones-2013-Intrachain Dynamics of Large.pdf
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1.12 MB
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Author(s)
Jones, Jeremy Joseph
van der Maarel, Johan R. C.
Doyle, Patrick S.
Date Issued
February 2013
Journal
Physical Review Letters
Publisher
American Physical Society
Citation
Jones, Jeremy J., Johan R. C. van der Maarel, and Patrick S. Doyle. "Intrachain Dynamics of Large dsDNA Confined to Slitlike Channels." Physical Review Letters 110.6 (2013): 068101 [5 pages]. © 2013 American Physical Society. Web.
Version
Final published version
Abstract
Exploration of intrachain hydrodynamics of dsDNA within channels has been limited to indirect analysis of global coil dynamics. In this Letter, we isolate hydrodynamic interactions within single molecules of dsDNA confined to slitlike channels by making use of density covariance measurements. We show that the strength of hydrodynamic interactions in DNA is dependent on the intrachain correlation length and that screening by symmetry in slitlike confinement results in a screening length that is proportional channel height. Moreover, we directly show the partial draining nature of the blobs formed by dsDNA in slits and predict under what conditions a dsDNA blob should obey nondraining Zimm behavior.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1103/PhysRevLett.110.068101
