Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation
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nihms-1679388.pdf
Description
Accepted version
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943.59 KB
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Checksum (MD5)
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Author(s)
Rodriguez, Jacob
Dhanjee, Heemal H
Buchwald, Stephen L
Date Issued
January 2021
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Rodriguez, Jacob, Dhanjee, Heemal H and Buchwald, Stephen L. 2021. "Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation." Organic Letters, 23 (3).
Version
Author's final manuscript
Abstract
© 2021 American Chemical Society. Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate amphiphilic ligands is presented. In this one-step protocol, the temperature and addition of fuming sulfuric acid were carefully controlled to arrive at sulfonated biaryl monophosphine ligands in high yields with >95% regioselectivity without the need for chromatographic purification.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1021/ACS.ORGLETT.0C04001
