Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion
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Kamm_Extracellular matrix.pdf
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Author(s)
Shin, Yoojin
Kim, Hyunju
Han, Sewoon
Won, Jihee
Jeong, Hyo Eun
Lee, Eun-Sook
Kim, Jae-Hong
Chung, Seok
Kamm, Roger Dale
Date Issued
November 2012
Journal
Advanced Healthcare Materials
Publisher
Wiley Blackwell
Citation
Shin, Yoojin, Hyunju Kim, Sewoon Han, Jihee Won, Hyo Eun Jeong, Eun-Sook Lee, Roger D. Kamm, Jae-Hong Kim, and Seok Chung. “Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion.” Advanced Healthcare Materials 2, no. 6 (November 26, 2012): 790–794.
Version
Author's final manuscript
Abstract
Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
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DOI of Published Version
https://doi.org/10.1002/adhm.201200320
