An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation
Name
hou-jasonhou-SM-MAS-2023-thesis.pdf
Description
Thesis PDF
Size
29.94 MB
Format
Adobe PDF
Checksum (MD5)
f512380186f85306c1e51bb0f36f3067
Author(s)
Hou, Jason F.
Advisor(s)
Dagdeviren, Canan
Date Issued
June 2023
Publisher
Massachusetts Institute of Technology
Abstract
Precise neurostimulation has potential to revolutionize therapies for neurological disorders. However, current neural interfaces targeting the deep brain face significant limitations in spatial resolution and potency due to tissue attenuation. We developed an implantable piezoelectric ultrasound stimulator (ImPULS) that generates an ultrasonic focal point pressure of 100 kPa and can non-genetically modulate the activity of neurons. We demonstrated that ImPULS can i) excite neurons in a mouse hippocampal slice ex vivo, ii) activate cells in the hippocampus of an anesthetized mouse to induce expression of activity-dependent gene c-Fos, and iii) stimulate dopaminergic neurons in the substantia nigra pars compacta (SNc) to elicit time-locked modulation of nigrostriatal dopamine release. This work introduces a novel, non-genetic ultrasound platform for spatially localized neural stimulation.
MIT Department
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
Terms of Use
In Copyright - Educational Use Permitted
Copyright retained by author(s)
Persistent DSpace Link
