Actin-based force generation and cell adhesion in tissue morphogenesis
Name
nihms-1718207.pdf
Description
Accepted version
Size
1.62 MB
Format
Adobe PDF
Checksum (MD5)
4145a8db315403bcd38dfc42aa6fb6a7
Author(s)
Clarke, D Nathaniel
Martin, Adam C
Date Issued
2021
Journal
Current Biology
Publisher
Elsevier BV
Citation
Clarke, D Nathaniel and Martin, Adam C. 2021. "Actin-based force generation and cell adhesion in tissue morphogenesis." Current Biology, 31 (10).
Version
Author's final manuscript
Abstract
The generation of organismal form - morphogenesis - arises from forces produced at the cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here, we review how mechanisms of actin-based force generation are deployed during animal morphogenesis to sculpt organs and organisms. Furthermore, we consider how cytoskeletal forces are coupled through cell adhesions to propagate across tissues, and discuss cases where cytoskeletal force or adhesion is patterned across a tissue to direct shape changes. Together, our review provides a conceptual framework that reflects our current understanding of animal morphogenesis and gives perspectives on future opportunities for study.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CUB.2021.03.031
