Selective Release of Multiple DNA Oligonucleotides from Gold Nanorods
Name
Multiple Release - ACS Nano R8.pdf
Description
Main article
Size
665.39 KB
Format
Adobe PDF
Checksum (MD5)
0bb9ca4df9971ab2261a5867203d05ae
Author(s)
Wijaya, Andy
Schaffer, Stefan Benjamin
Pallares, Ivan
Hamad-Schifferli, Kimberly
Date Issued
January 2009
Journal
ACS Nano
Publisher
American Chemical Society
Citation
Wijaya, Andy et al. “Selective Release of Multiple DNA Oligonucleotides from Gold Nanorods.” ACS Nano 3.1 (2009): 80-86.
Version
Author's final manuscript
Abstract
Combination therapy, or the use of multiple drugs, has been proven to be effective for complex diseases, but the differences in chemical properties and pharmacokinetics can be challenging in terms of the loading, delivering, and releasing multiple drugs. Here we demonstrate that we can load and selectively release two different DNA oligonucleotides from two different gold nanorods. DNA was loaded on the nanorods via thiol conjugation. Selective releases were induced by selective melting of gold nanorods via ultrafast laser irradiation at the nanorods’ longitudinal surface plasmon resonance peaks. Excitation at one wavelength could selectively melt one type of gold nanorods and selectively release one type of DNA strand. Releases were efficient (50−80%) and externally tunable by laser fluence. Released oligonucleotides were still functional. This proof of concept is potentially a powerful method for multiple-drug delivery strategies.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
http://dx.doi.org/10.1021/nn800702n
