7.340 Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance, Spring 2004
Author(s)
Halme, Dina Gould
Alternative Title
Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance
Date Issued
June 2004
Abstract
Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease-specific immune evasion and the mechanisms used by pathogens to prevail over their hosts' immune systems are discussed. Also considered is what these host-pathogen interactions reveal about the normal function of the immune system and basic cell biological processes, such as protein maturation and degradation.
Subjects
immunology
immune system
immune evasion
pathogen
effector function
infections
Human cytomegalovirus
Human Immunodeficiency Virus
CD4 cells
CD8 cells
T cells
surace receptors
cell lysis
host-pathogen interactions
host surveillance
antibodies
MHC class I
blood-borne pathogens
macrophages
phagocytosis
endocytosis
degradation
antigen
apoptosis
cytokines
immune response
MIT Department
Massachusetts Institute of Technology. Department of Biology
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