Gut Microbiota and the Paradox of Cancer Immunotherapy
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Poutahidis-2014-Gut Microbiota and t.pdf
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Author(s)
Poutahidis, Theofilos
Kleinewietfeld, Markus
Erdman, Susan E.
Date Issued
April 2014
Journal
Frontiers in Immunology
Publisher
Frontiers Research Foundation
Citation
Poutahidis, Theofilos, Markus Kleinewietfeld, and Susan E. Erdman. “Gut Microbiota and the Paradox of Cancer Immunotherapy.” Front. Immunol. 5 (April 7, 2014).
Version
Final published version
Abstract
It is recently shown that beneficial environmental microbes stimulate integrated immune and neuroendocrine factors throughout the body, consequently modulating regulatory T-lymphocyte phenotypes, maintaining systemic immune balance, and determining the fate of preneoplastic lesions toward regression while sustaining whole body good health. Stimulated by a gut microbiota-centric systemic homeostasis hypothesis, we set out to explore the influence of the gut microbiome to explain the paradoxical roles of regulatory T-lymphocytes in cancer development and growth. This paradigm shift places cancer prevention and treatment into a new broader context of holobiont engineering to cultivate a tumor-suppressive macroenvironment.
MIT Department
Massachusetts Institute of Technology. Division of Comparative Medicine
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.3389/fimmu.2014.00157
