Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts
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Buchwald_Mild and general.pdf
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2.04 MB
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Author(s)
Yang, Yang
Oldenhuis, Nathan J.
Buchwald, Stephen Leffler
Date Issued
November 2012
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Yang, Yang, Nathan J. Oldenhuis, and Stephen L. Buchwald. “Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts.” Angewandte Chemie International Edition 52, no. 2 (November 22, 2012): 615–619.
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Author's final manuscript
Abstract
A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd[superscript 0] species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1002/anie.201207750
