Seeing into Hi-C: How our scientific connectivity revealed the close connections in our DNA to be a work of art
Name
012101_1_5.0283280.pdf
Description
Published version
Size
1.66 MB
Format
Adobe PDF
Checksum (MD5)
a26fc123b0fecf5fc9ef84d46caece31
Author(s)
Griffiths, Mary
Austin, Caroline
Dekker, Job
Mirny, Leonid
Harris, Sarah
Date Issued
January 22, 2026
Journal
Biophysics Reviews
Publisher
AIP Publishing
Citation
Mary Griffiths, Caroline Austin, Job Dekker, Leonid Mirny, Sarah Harris; Seeing into Hi-C: How our scientific connectivity revealed the close connections in our DNA to be a work of art. Biophysics Rev. 1 March 2026; 7 (1): 012101.
Version
Final published version
Abstract
Scientific data can be beautiful. An example where the data itself have a particularly striking appearance even before any scientific meaning has been ascribed is the so-called “Hi-C” chromatin interaction map with its distinct checker-board patterns which when combined with simulations have revealed the complex structure of the folded genome. Here, we describe an art-science collaboration which arose through combining local and global inter-personal connections, and which illustrates the equivalent short- and long-range contacts within folded genomes.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Physics
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1063/5.0283280
