Design of a rapid, continuous, small-scale device for creating dry powders from concentrated suspensions containing active pharmaceutical ingredients
Name
772528592-MIT.pdf
Description
Full printable version
Size
3.35 MB
Format
Adobe PDF
Checksum (MD5)
855beef43c298197cfa6a12bc1b68a84
Author(s)
Correll, Eric Owen
Advisor(s)
Alexander H. Slocum.
Date Issued
2011
Publisher
Massachusetts Institute of Technology
Abstract
Current methods of producing pharmaceutical compounds are large batch processes. The minimum time-to-patient for drug manufacturing is approximately 100 days. Using a continuous manufacturing process, the time-to-patient could be reduced to less than ten days. The scope of this paper encompasses the design of a machine for the desiccation of a mixture of solvent and pharmaceutical compound. The goal of this project was to provide a small-scale, high throughput method of continuous pharmaceutical drug drying for Novartis-MIT Center for Continuous Manufacturing. Specifications included a product flow rate of 100 grams per hour and a final product form of flowable powder. Several machines were built and tested, with the final design being comprised of a convective drum dryer and a modular continuous vacuum dryer.
Description
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, June 2011.
"February 2011." Cataloged from PDF version of thesis.
Includes bibliographical references (p. 14).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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