Mechano-genomic regulation of coronaviruses and its interplay with ageing
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NRM-20-053_Shivashankar-Clean-Final.pdf
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333.81 KB
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Author(s)
Uhler, Caroline
Shivashankar, G. V.
Date Issued
April 2020
Journal
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Citation
Uhler, Caroline and G. V. Shivashankar. "Mechano-genomic regulation of coronaviruses and its interplay with ageing." Nature Reviews Molecular Cell Biology 21, 5 (April 2020): 247–248. © 2020 Springer Nature Limited
Version
Author's final manuscript
Abstract
Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.
MIT Department
Massachusetts Institute of Technology. Laboratory for Information and Decision Systems
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/s41580-020-0242-z
