Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
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Earnshaw_2013-Esperanto for histones.pdf
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97.89 KB
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Author(s)
Cheeseman, Iain M
Date Issued
April 2013
Journal
Chromosome Research
Publisher
Springer-Verlag
Citation
Earnshaw, W. C., R. C. Allshire, B. E. Black, K. Bloom, B. R. Brinkley, W. Brown, I. M. Cheeseman, et al. “Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.” Chromosome Research 21, no. 2 (April 12, 2013): 101-106.
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Final published version
Abstract
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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DOI of Published Version
https://doi.org/10.1007/s10577-013-9347-y
