Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System
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Buchwald_Rapid and Efficient.pdf
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Author(s)
Chen, Mao
Buchwald, Stephen Leffler
Date Issued
September 2013
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Chen, Mao, and Stephen L. Buchwald. “Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System.” Angewandte Chemie International Edition 52, no. 44 (September 5, 2013): 11628–11631.
Version
Author's final manuscript
Abstract
The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF[subscript 3]CO[subscript 2]K as the trifluoromethyl source. The process has the advantage of short reaction times and uses convenient [CF[subscript 3]] sources.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/anie.201306094
