Detection of morphological markers of vulnerable atherosclerotic plaque using multimodal spectroscopy
Name
Scepanovic-2006-Detection of morphological.pdf
Size
746.27 KB
Format
Adobe PDF
Checksum (MD5)
958198eadebfb01bd9a65c273f069127
Author(s)
Fitzmaurice, Maryann
Gardecki, Joseph A.
Angheloiu, George O.
Awasthi, Samir
Motz, Jason T.
Kramer, John R.
Feld, Michael S.
Scepanovic, Obrad R.
Dasari, Ramachandra Rao
Date Issued
March 2006
Journal
Journal of Biomedical Optics
Publisher
SPIE
Citation
Scepanovic, Obrad R., Maryann Fitzmaurice, Joseph A. Gardecki, George O. Angheloiu, Samir Awasthi, Jason T. Motz, John R. Kramer, Ramachandra R. Dasari, and Michael S. Feld. “Detection of Morphological Markers of Vulnerable Atherosclerotic Plaque Using Multimodal Spectroscopy.” Journal of Biomedical Optics 11, no. 2 (2006): 021007. © 2006 Society of Photo-Optical Instrumentation Engineers
Version
Final published version
Abstract
Vulnerable plaques, which are responsible for most acute ischemic events, are presently invisible to x-ray angiography. Their primary morphological features include a thin or ulcerated fibrous cap, a large necrotic core, superficial foam cells, and intraplaque hemorrhage. We present evidence that multimodal spectroscopy (MMS), a novel method that combines diffuse reflectance spectroscopy (DRS), intrinsic fluorescence spectroscopy (IFS), and Raman spectroscopy (RS), can detect these markers of plaque vulnerability. To test this concept, we perform an MMS feasibility study on 17 human carotid artery specimens. Following the acquisition of spectra, each specimen is histologically evaluated. Two parameters from DRS, hemoglobin concentration and a scattering parameter, are used to detect intraplaque hemorrhage and foam cells; an IFS parameter that relates to the amount of collagen in the topmost layers of the tissue is used to detect the presence of a thin fibrous cap; and an RS parameter related to the amount of cholesterol and necrotic material is used to detect necrotic core. Taken together, these spectral parameters can generally identify the vulnerable plaques. The results indicate that MMS provides depth-sensitive and complementary morphological information about plaque composition. A prospective in vivo study will be conducted to validate these findings.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Physics
Massachusetts Institute of Technology. Spectroscopy Laboratory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1117/1.2187943
