Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain
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Sepulcre-2012-Stepwise Connectivit.pdf
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Author(s)
Sepulcre, Jorge
Sabuncu, Mert R.
Yeo, Thomas B.
Lui, Hesheng
Johnson, Keith A.
Date Issued
May 2012
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Sepulcre, J. et al. “Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain.” Journal of Neuroscience 32.31 (2012): 10649–10661. Web.
Version
Final published version
Abstract
How human beings integrate information from external sources and internal cognition to produce a coherent experience is still not well understood. During the past decades, anatomical, neurophysiological and neuroimaging research in multimodal integration have stood out in the effort to understand the perceptual binding properties of the brain. Areas in the human lateral occipitotemporal, prefrontal, and posterior parietal cortices have been associated with sensory multimodal processing. Even though this, rather patchy, organization of brain regions gives us a glimpse of the perceptual convergence, the articulation of the flow of information from modality-related to the more parallel cognitive processing systems remains elusive. Using a method called stepwise functional connectivity analysis, the present study analyzes the functional connectome and transitions from primary sensory cortices to higher-order brain systems. We identify the large-scale multimodal integration network and essential connectivity axes for perceptual integration in the human brain.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1523/jneurosci.0759-12.2012
