Bacteria and the Aging and Longevity of Caenorhabditis elegans
Name
Ann_Rev_Gen_KIMCombined.pdf
Description
text and figures combined
Size
451.84 KB
Format
Adobe PDF
Checksum (MD5)
ea200074d2550f927298e1246b4cd69c
Author(s)
Kim, Dennis H.
Date Issued
November 2013
Journal
Annual Review of Genetics
Publisher
Annual Reviews
Citation
Kim, Dennis H. “ Bacteria and the Aging and Longevity of Caenorhabditis Elegans .” Annu. Rev. Genet. 47, no. 1 (November 23, 2013): 233–246.
Version
Author's final manuscript
Abstract
The molecular genetic analysis of longevity of Caenorhabditis elegans has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that interactions between C. elegans and its microbial environment may influence the aging and longevity of this simple host organism. Experimental evidence supports a role for bacteria in affecting longevity through distinct mechanisms—as a nutrient source, as a potential pathogen that induces double-edged innate immune and stress responses, and as a coevolved sensory stimulus that modulates neuronal signaling pathways regulating longevity. Motivating this review is the anticipation that the molecular genetic dissection of the integrated host immune, stress, and neuroendocrine responses to microbes in C. elegans will uncover basic insights into the cellular and organismal physiology that governs aging and longevity.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1146/annurev-genet-111212-133352
