Identification of cell cycle-targeting microRNAs through genome-wide screens
Name
kccy-16-23-1380132.pdf
Description
Published version
Size
932.71 KB
Format
Adobe PDF
Checksum (MD5)
6fd1ec25b5540b76be74162e178709f9
Author(s)
Bogorad, Roman
Yin, Hao
Anderson, Daniel Griffith
Date Issued
November 14, 2017
Journal
Cell cycle
Publisher
Informa UK Limited
Citation
Hydbringa, Per, Yinan Wang, Roman L. Bogorad, Hao Yin, Daniel G. Andersond, Cheng Li, and Piotr Sicinski. "Identification of cell cycle-targeting microRNAs through genome-wide screens." Cell cycle, 16, no. 23 (Nov. 2017): pp. 2241-2248. © 2017 The Author(s)
Version
Final published version
Abstract
By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients.
Subjects
Developmental Biology
Cell Biology
Molecular Biology
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1080/15384101.2017.1380132
