Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations
Name
Klibanov-2011-Jan-Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations.pdf
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Author(s)
Hsu, Bryan Boen
Wong, Sze Yinn
Chen, Jianzhu
Klibanov, Alexander M.
Hammond, Paula T
Date Issued
January 2011
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Hsu, B. B. et al. “Mechanism of Inactivation of Influenza Viruses by Immobilized Hydrophobic Polycations.” Proceedings of the National Academy of Sciences 108.1 (2011) : 61-66. ©2011 by the National Academy of Sciences.
Version
Final published version
Abstract
N,N-Dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural damage and inactivation; subsequently, viral RNA is released into solution, while proteins remain adsorbed.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1017012108
