Multiscale technologies for treatment of ischemic cardiomyopathy
Name
nihms920273.pdf
Description
Accepted version
Size
978.56 KB
Format
Unknown
Checksum (MD5)
a0529bc5f17edc84a381a533f4d9207f
Author(s)
Mahmoudi, Morteza
Yu, Mikyung
Serpooshan, Vahid
Wu, Joseph C
Langer, Robert S
Lee, Richard T
Karp, Jeffrey Michael
Farokhzad, Omid C
Date Issued
2017
Journal
Nature Nanotechnology
Publisher
Springer Nature
Version
Author's final manuscript
Abstract
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. The adult mammalian heart possesses only limited capacity for innate regeneration and the response to severe injury is dominated by the formation of scar tissue. Current therapy to replace damaged cardiac tissue is limited to cardiac transplantation and thus many patients suffer progressive decay in the heart's pumping capacity to the point of heart failure. Nanostructured systems have the potential to revolutionize both preventive and therapeutic approaches for treating cardiovascular disease. Here, we outline recent advancements in nanotechnology that could be exploited to overcome the major obstacles in the prevention of and therapy for heart disease. We also discuss emerging trends in nanotechnology affecting the cardiovascular field that may offer new hope for patients suffering massive heart attacks.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/NNANO.2017.167
