Evolutionary principles of modular gene regulation in yeasts
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Regev_Evolutionary principles.pdf
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Author(s)
Thompson, Dawn A.
Roy, Sushmita
Chan, Michelle Mei Wah
Styczynsky, Mark P.
Pfiffner, Jenna
French, Courtney
Socha, Amanda
Thielke, Anne
Napolitano, Sara
Muller, Paul
Date Issued
June 2013
Journal
eLife
Publisher
eLife Sciences Publications, Ltd
Citation
Thompson, D. A., S. Roy, M. Chan, M. P. Styczynsky, J. Pfiffner, C. French, A. Socha, et al. “Evolutionary principles of modular gene regulation in yeasts.” eLife 2, no. 0 (January 8, 2013): e00603-e00603.
Version
Final published version
Abstract
Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular regulatory programs along a time course of growth on glucose over 300 million years. We found that modules have diverged proportionally to phylogenetic distance, with prominent changes in gene regulation accompanying changes in lifestyle and ploidy, especially in carbon metabolism. Paralogs have significantly contributed to regulatory divergence, typically within a very short window from their duplication. Paralogs from a whole genome duplication (WGD) event have a uniquely substantial contribution that extends over a longer span. Similar patterns occur when considering the evolution of the heat shock regulatory program measured in eight of the species, suggesting that these are general evolutionary principles.
MIT Department
Massachusetts Institute of Technology. Computational and Systems Biology Program
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.7554/eLife.00603
