Polypyrrole : an interactive substrate for bone regeneration
Name
46240977-MIT.pdf
Description
Full printable version
Size
7.49 MB
Format
Adobe PDF
Checksum (MD5)
7173e85043a5163a880bbfdc0edae293
Author(s)
Rahman, Nahid, S.M. Massachusetts Institute of Technology.
Advisor(s)
Robert S. Langer.
Alternative Title
Interactive substrate for bone regeneration
Date Issued
1998
Publisher
Massachusetts Institute of Technology
Abstract
Current methods of bone repair rely on autografts (bone from a donor site) and allografts (bone from human cadaver). However, these methods are plagued with disadvantages. There is a clear and urgent need to provide alternatives for regenerating and repairing bone. Bone is known to be one of the many connective tissues in the body that are responsive to exogenous electrical stimulation. Based on this principle, this thesis explores the potential of using an electrically conducting polymer, polypyrrole, as a substrate for bone regeneration. Optically transparent thin films of polypyrrole, with a polyanionic dopant, poly(styrenesulfonate), were synthesized electrochemically and characterized by X-Ray Photoelectron Spectroscopy, UV/VIS spectroscopy, Scanning Electron Microscopy and by electrical conductivity measurements. In this study, Bone Marrow Stromal Cells (BMSC), which are the progenitor cells to bone cells (osteoblasts), were used as the in vitro model system. Their viability, proliferation and differentiation capabilities were evaluated on polypyrrole, in the absence and presence of electrical stimulation. Results indicate that polypyrrole is ideally suited as a substratum for BMSC growth and differentiation. The application of an electrical stimulus through the polypyrrole substrate was found to induce the differentiation of BMSC towards an osteogenic lineage. Thus, polypyrrole, by virtue of its conductive properties, its in vitro biocompatibility and its flexibility in altering surface characteristics, has an exciting potential as a suitable interactive substrate for bone regeneration.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1998.
Includes bibliographical references (leaves 59-68).
Subjects
Materials Science and Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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