In vitro models of the metastatic cascade: from local invasion to extravasation
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Kamm_In vitro models.pdf
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Author(s)
Bersini, S.
Moretti, Matteo
Jeon, Jessie S
Kamm, Roger Dale
Date Issued
June 2014
Journal
Drug Discovery Today
Publisher
Elsevier
Citation
Bersini, S., J.S. Jeon, Matteo Moretti, and R.D. Kamm. “In Vitro Models of the Metastatic Cascade: From Local Invasion to Extravasation.” Drug Discovery Today 19, no. 6 (June 2014): 735–742.
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Author's final manuscript
Abstract
A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell–cell and cell–matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.drudis.2013.12.006
