Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines
Name
fimmu-13-840104.pdf
Size
1.29 MB
Format
Adobe PDF
Checksum (MD5)
76b4c3cf4e8838bb84c9107d0f410d7d
Author(s)
Hou, Jue
Ye, Weijian
Chen, Jianzhu
Date Issued
February 24, 2022
Journal
Frontiers in Immunology
Publisher
Frontiers Media SA
Citation
Hou, Jue, Ye, Weijian and Chen, Jianzhu. 2022. "Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines." Frontiers in Immunology, 13.
Version
Final published version
Abstract
Dengue is the most common arboviral disease caused by one of four distinct but closely related dengue viruses (DENV) and places significant economic and public health burdens in the endemic areas. A dengue vaccine will be important in advancing disease control. However, the effort has been challenged by the requirement to induce effective protection against all four DENV serotypes and the potential adverse effect due to the phenomenon that partial immunity to DENV may worsen the symptoms upon subsequent heterotypic infection. Currently, the most advanced dengue vaccines are all tetravalent and based on recombinant live attenuated viruses. CYD-TDV, developed by Sanofi Pasteur, has been approved but is limited for use in individuals with prior dengue infection. Two other tetravalent live attenuated vaccine candidates: TAK-003 by Takeda and TV003 by National Institute of Allergy and Infectious Diseases, have completed phase 3 and phase 2 clinical trials, respectively. This review focuses on the designs and evaluation of TAK-003 and TV003 vaccine candidates in humans in comparison to the licensed CYD-TDV vaccine. We highlight specific lessons from existing studies and challenges that must be overcome in order to develop a dengue vaccine that confers effective and balanced protection against all four DENV serotypes but with minimal adverse effects.
MIT Department
Singapore-MIT Alliance in Research and Technology (SMART)
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fimmu.2022.840104
