Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease
Name
Buehler_Molecular and.pdf
Size
228.44 KB
Format
Adobe PDF
Checksum (MD5)
8e497a5b06229c8ee6f889539e4803a3
Author(s)
Uzel, Sebastien Guy Marcel
Buehler, Markus J
Date Issued
February 2010
Journal
Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010)
Publisher
American Society of Mechanical Engineers
Citation
Uzel, Sebastien, and Markus J. Buehler. “Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease.” Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010) Feb. 7–10, Houston, Texas, USA 2010. 289-290. ©2010 ASME.
Version
Final published version
Abstract
Collagen is a crucial structural protein material, formed through a hierarchical assembly of tropocollagen molecules, arranged in collagen fibrils that constitute the basis for larger-scale fibrils and fibers. Osteogenesis imperfecta is a genetic disorder in collagen characterized by mechanically weakened tendon, fragile bones, skeletal deformities and in severe cases prenatal death. Even though many studies have attempted to associate specific mutation types with phenotypic severity, the mechanisms by which a single point mutation influences the mechanical behavior of tissues at multiple length-scales remain unknown. In this study, we report a series of systematic molecular scale based bottom-up computational experiments focused on pure collagenous tissue, carried out using atomistic-level molecular dynamics (MD), adaptive Poison-Boltzmann solver (APBS) calculations, and a mesoscale molecular model of collagen fibrils.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1115/NEMB2010-13160
