Activated Metals to Generate Heat for Biomedical Applications
Name
remlova-et-al-2023-activated-metals-to-generate-heat-for-biomedical-applications.pdf
Description
Published version
Size
10.67 MB
Format
Adobe PDF
Checksum (MD5)
565ce5c81a244573d35f1c1eb8c7e846
Author(s)
Remlova, Eva
Feig, Vivian Rachel
Kang, Ziliang
Patel, Ashka
Ballinger, Ian
Ginzburg, Anna
Kuosmanen, Johannes
Fabian, Niora
Ishida, Keiko
Jenkins, Joshua
Date Issued
August 16, 2023
Journal
ACS Materials Letters
Publisher
American Chemical Society
Citation
ACS Materials Lett. 2023, 5, 9, 2508–2517
Version
Final published version
Abstract
Delivering heat in vivo could enhance a wide range of biomedical therapeutic and diagnostic technologies, including long-term drug delivery devices and cancer treatments. To date, providing thermal energy is highly power-intensive, rendering it oftentimes inaccessible outside of clinical settings. We developed an in vivo heating method based on the exothermic reaction between liquid-metal-activated aluminum and water. After establishing a method for consistent activation, we characterized the heat generation capabilities with thermal imaging and heat flux measurements. We then demonstrated one application of this reaction: to thermally actuate a gastric resident device made from a shape-memory alloy called Nitinol. Finally, we highlight the advantages and future directions for leveraging this novel in situ heat generation method beyond the showcased example.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/acsmaterialslett.3c00581
