Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer
Name
nihms-1569364.pdf
Description
Accepted version
Size
627.5 KB
Format
Unknown
Checksum (MD5)
e459130d497d49e0eb41b21c177676a2
Author(s)
Sivanand, Sharanya
Vander Heiden, Matthew G
Date Issued
February 2020
Journal
Cancer Cell
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2020 Elsevier Inc. Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CCELL.2019.12.011
