Lorentz-force actuated needle-free injection for intratympanic pharmaceutical delivery
Name
858866517-MIT.pdf
Description
Full printable version
Size
13.74 MB
Format
Adobe PDF
Checksum (MD5)
6cad0db8b4950e45a70dbf3ac1efbbf8
Author(s)
Cloutier, Alison (Alison Marie)
Advisor(s)
Ian W. Hunter.
Date Issued
2013
Publisher
Massachusetts Institute of Technology
Abstract
Delivery of pharmaceuticals to the inner ear via injection through the tympanic membrane is a method of local drug delivery that provides a non-invasive, outpatient procedure to treat many of the disorders and diseases that plague the inner ear. The real-time controlled linear Lorentz-force actuated jet injector developed in the MIT BioInstrumentation lab was found to be a feasible technology for possible improvement over current intratympanic drug delivery methods. Jet injection holes using a nozzle with a 50 [mu]m orifice were found to be significantly smaller than those made using a standard, 0.31 mm (30-gauge) hypodermic needle. The feasibility of using the jet injector to deliver drug to the inner ear with less tissue damage than seen in standard procedures is shown offering an avenue for improved inner ear drug delivery methods and technology.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2013.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 113-118).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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