Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients
Name
advs.202001677.pdf
Description
Published version
Size
2.36 MB
Format
Adobe PDF
Checksum (MD5)
9a5119e280d054b1d6458a98eebda036
Author(s)
Chen, Liang-Hsun
Cheng, Li-Chiun
Doyle, Patrick S
Date Issued
2020
Journal
Advanced Science
Publisher
Wiley
Version
Final published version
Abstract
© 2020 The Authors. Published by Wiley-VCH GmbH Nanoemulsions have become ideal candidates for loading hydrophobic active ingredients and enhancing their bioavailability in the pharmaceutical, food, and cosmetic industries. However, the lack of versatile carrier platforms for nanoemulsions hinders advanced control over their release behavior. In this work, a method is developed to encapsulate nanoemulsions in alginate capsules for the controlled delivery of lipophilic active ingredients. Functional nanoemulsions loaded with active ingredients and calcium ions are first prepared, followed by encapsulation inside alginate shells. The intrinsically high viscosity of the nanoemulsions ensures the formation of spherical capsules and high encapsulation efficiency during the synthesis. Moreover, a facile approach is developed to measure the nanoemulsion release profile from capsules through UV–vis measurement without an additional extraction step. A quantitative analysis of the release profiles shows that the capsule systems possess a tunable, delayed-burst release. The encapsulation methodology is generalized to other active ingredients, oil phases, nanodroplet sizes, and chemically crosslinked inner hydrogel cores. Overall, the capsule systems provide promising platforms for various functional nanoemulsion formulations.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/ADVS.202001677
