Magnetic Barcoded Hydrogel Microparticles for Multiplexed Detection
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Doyle_Irogel microparticles.pdf
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1.65 MB
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Author(s)
Bong, Ki Wan
Chapin, Stephen C.
Doyle, Patrick S.
Date Issued
February 2010
Journal
Langmuir
Publisher
American Chemical Society
Citation
Bong, Ki Wan, Stephen C. Chapin, and Patrick S. Doyle. Magnetic Barcoded Hydrogel Microparticles for Multiplexed Detection. Langmuir 26, no. 11 (June 2010): 8008-8014. doi:10.1021/la904903g.
Version
Author's final manuscript
Abstract
Magnetic polymer particles have been used in a wide variety of applications ranging from targeting and separation to diagnostics and imaging. Current synthesis methods have limited these particles to spherical or deformations of spherical morphologies. In this paper, we report the use of stop flow lithography to produce magnetic hydrogel microparticles with a graphical code region, a probe region, and a magnetic tail region. These anisotropic multifunctional magnetic polymer particles are an enhanced version of previously synthesized “barcoded” particles ( Science, 2007, 315, 1393−1396) developed for the sensitive and rapid multiplexed sensing of nucleic acids. The newly added magnetic region has acquired dipole moments in the presence of weak homogeneous magnetic fields, allowing the particles to align along the applied field direction. The novel magnetic properties have led to practical applications in the efficient orientation and separation of the barcoded microparticles during biological assays without disrupting detection capabilities.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/la904903g
