350-μm side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus
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Kim-2013-350.pdf
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Author(s)
Kim, Jun Ki
Yun, Seok Hyun (Andy)
Choi, Jin Woo
Date Issued
April 2013
Journal
Journal of Biomedical Optics
Publisher
SPIE
Citation
Kim, Jun Ki. “350-μm side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus.” Journal of Biomedical Optics 18, no. 5 (May 1, 2013): 050502. © 2013 Society of Photo-Optical Instrumentation Engineers
Version
Final published version
Abstract
Miniature endoscopic probes offer a solution for deep brain imaging by overcoming the limited depth of intravital microscopy. We describe a small-diameter (350 μm) graded-index optical probe with a side-view design for in vivo cellular imaging of the mammalian brain. The side-view probe provides a unique view of the vertical network of neurons and penetrating blood vessels. At a given insertion site, the translational and rotational scanning of the probe provides access to a large tissue area (>1 mm[superscript 2]) across the cortex, hippocampus, thalamus, and hypothalamus.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1117/1.JBO.18.5.050502
