Peptide Fragment Coupling Using a Continuous-Flow Photochemical Rearrangement of Nitrones
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Jamison_Peptide fragment.pdf
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467.62 KB
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Author(s)
Zhang, Yuan
Blackman, Melissa L.
Leduc, Andrew B.
Jamison, Timothy F.
Date Issued
March 2013
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Zhang, Yuan, Melissa L. Blackman, Andrew B. Leduc, and Timothy F. Jamison. “Peptide Fragment Coupling Using a Continuous-Flow Photochemical Rearrangement of Nitrones.” Angewandte Chemie International Edition 52, no. 15 (April 8, 2013): 4251-4255.
Version
Author's final manuscript
Abstract
A general approach for amide bond formation by way of a continuous-flow photochemical rearrangement of nitrones was described (see scheme). Simple aryl-alkyl amide bonds as well as complex peptide bonds were constructed efficiently with a residence time less than 20 minutes. A tetrapeptide was synthesized in this way and the method could be applied to peptide fragment coupling.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1002/anie.201300504
