Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport
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Author(s)
Kim, Minkyu
Chen, Wesley George
Ribbeck, Katharina
Olsen, Bradley D
Kang, Jeon Woong
Glassman, Matthew J.
Date Issued
June 2015
Journal
Advanced Materials
Publisher
Wiley Blackwell
Citation
Kim, Minkyu et al. “Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport.” Advanced Materials 27.28 (2015): 4207–4212.
Version
Author's final manuscript
Abstract
Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo–carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Laser Biomedical Research Center
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adma.201500752
