Molecular definition of the identity and activation of natural killer cells
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Regev_Molecular definition.pdf
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2.73 MB
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Author(s)
Bezman, Natalie A.
Kim, Charles C.
Sun, Joseph C.
Min-Oo, Gundula
Hendricks, Deborah W.
Kamimura, Yosuke
Best, J. Adam
Goldrath, Ananda W.
Lanier, Lewis L.
Regev, Aviv
Date Issued
August 2012
Journal
Nature Immunology
Citation
Bezman, Natalie A, Charles C Kim, Joseph C Sun, Gundula Min-Oo, Deborah W Hendricks, Yosuke Kamimura, J Adam Best, et al. “Molecular definition of the identity and activation of natural killer cells.” Nature Immunology 13, no. 10 (August 19, 2012): 1000-1009.
Version
Author's final manuscript
Abstract
Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8+ T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states.
Description
available in PMC 2013 April 01.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
http://dx.doi.org/10.1038/ni.2395
